Preheat the oven to 350°F (175°C).

In a large mixing bowl, combine the ground beef, breadcrumbs, chopped onion, milk, egg, salt, pepper, and Worcestershire sauce.

Transfer the mixture to a loaf pan and shape it into a loaf.

In a small bowl, mix together the ketchup and brown sugar for the glaze.

Spread half of the glaze over the top of the meat loaf.

Place the loaf pan in the preheated oven and bake for 1 hour.

After 45 minutes of baking, remove the meat loaf and spread the remaining glaze on top.

Use a meat thermometer to check if the internal temperature reaches 160°F (70°C).

Let the meat loaf rest for 10 minutes before slicing.