In a medium saucepan, combine the ketchup, water, brown sugar, Worcestershire sauce, apple cider vinegar, and mustard.

Stir in the onion powder, garlic powder, salt, and black pepper.

Place the saucepan over medium heat and stir occasionally until the mixture starts to bubble gently.

Reduce the heat to low and let the sauce simmer for about 10 minutes.

Taste the sauce and adjust any seasonings if necessary.

Remove from heat once the sauce has reached your desired consistency.

Pour the sauce over cooked ground beef, turkey, or your choice of protein.

If you have any sauce left, let it cool before storing it in an airtight container.