In a large skillet over medium heat, add the ground beef. Break it apart with a wooden spoon and cook until browned, about 5-7 minutes.

Add the chopped onion to the skillet with the beef. Cook until the onions are soft and translucent, about 3-4 minutes.

If there's excess grease in the skillet, carefully drain it off.

Add the ketchup, yellow mustard, brown sugar, chili powder, garlic powder, and Worcestershire sauce. Stir well to combine all the ingredients.

Reduce the heat to low and let the sauce simmer for 20 minutes.

After simmering, taste the sauce and add salt and pepper as needed.

Once ready, spoon the sauce generously over grilled hot dogs.

If you have any sauce left, let it cool and store it in an airtight container.