In a mixing bowl, combine the ground beef with salt, pepper, garlic powder, and onion powder.

Divide the meat mixture into four equal portions and shape them into patties.

Make a small indent in the center of each patty.

Preheat your grill or skillet over medium-high heat.

Place the patties on the grill or skillet, cooking for about 4-5 minutes per side.

Check for an internal temperature of 160°F for medium doneness.

During the last minute of cooking, place the buns cut-side down on the grill or skillet.

Place each patty on a bun and add your favorite toppings.

Serve the burgers immediately while they are hot.